BY INDUSTRIAL CHEMISTRY EXPERT [Mohan Kumar Jha & Hemant]
In the field of medicine,pharmacy and biotechnology ,drugs discovery are the process by which the drugs are produced or we can say discovered...
Now in the past days,,mostly drugs are discovered either by identifying the active ingredients from traditional remedies or by serendipitious discovery....
As our knowledge of disease increased to the extent so that we know that how disease and infection are controlled by the molecular and physicological level,,,scientist now try to find out those compoundes that are capable to modulate that molecule.....
Process of drugs development....
The process of drugs discovery involves the identification of candidates,synthesis,characterisation,screening, and assays for therepeutic efficacy..,,now once a compund has shown its value inthe test,,it will begin for drugs discovery i.e. clinical trials.....
--DRUG DISCOVERY--
In the field of medicine,pharmacy and biotechnology ,drugs discovery are the process by which the drugs are produced or we can say discovered...
Now in the past days,,mostly drugs are discovered either by identifying the active ingredients from traditional remedies or by serendipitious discovery....
As our knowledge of disease increased to the extent so that we know that how disease and infection are controlled by the molecular and physicological level,,,scientist now try to find out those compoundes that are capable to modulate that molecule.....
Process of drugs development....
The process of drugs discovery involves the identification of candidates,synthesis,characterisation,screening, and assays for therepeutic efficacy..,,now once a compund has shown its value inthe test,,it will begin for drugs discovery i.e. clinical trials.....
Drug targets...
The definition of "target" is something argued
within the pharmaceutical industry. Generally, that "target" is the
naturally existing cellular or molecular structure that involved in the
pathology of interest that the drug-in-development is meant to be act on.
However, the distinction between a "new" and "established"
target can be made without a fully knowledge of just what a "target"
is. This distinction is originally made by the pharmaceutical companies engaged
in discovery and development of therapeutics....
"Established targets" are those for which there is
a good scientific understanding, supported by the lengthy publication part, of
both how the target functions in normal physiology and how it is involves in
human pathology. This doesn’t implying that the mechanism of action of the drugs
that are thought to act through a particular established targets is fully
understood. Rather, "established" relates directly to the amount of
background information available on a target points, in particular functional
information. The more such information is available, the less investment is
(generally) required to develop a therapeutic directed against the target. The
process of gathering such functional information is called "target
validation" also in pharmaceutical industry parlance. Established targets
also include those that the pharmaceutical industry has had experience mounting
drug discovery campaigns against in the past; such a history provides
information on the chemical feasibility of developing a small molecular
therapeutic against the targets and can be provide licensing opportunities and
freedom to operate indicators with respect to smaller-molecule therapeutic
candidates.
Normally , "new targets" are all those targets
that are not "established targets" but which have been o are the
subject of drug discovery campaigns. These targets typically include newly
discovered proteins, or proteins whose function has now become clear as a
result of basic scientific research.
We would provide more about drigs discovery,development and other discovery arena...thanks for reading this article....
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